意义未明的单克隆丙种球蛋白病和冒烟型多发性骨髓瘤：发病机制、自然史及管理的最新进展
MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management.
作者信息
Rajkumar S Vincent
机构信息
Mayo Clinic College of Medicine, Division of Hematology, 200 First Avenue St., SW, Rochester, MN 55905, USA.
出版信息
Hematology Am Soc Hematol Educ Program. 2005:340-5. doi: 10.1182/asheducation-2005.1.340.
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.
意义未明的单克隆丙种球蛋白病（MGUS）和冒烟型多发性骨髓瘤（SMM）是无症状的癌前疾病，其特征为骨髓中出现单克隆浆细胞增殖且无终末器官损害。本文综述了MGUS和SMM在发病机制、自然病程及预后方面的最新进展。还讨论了一种利用M蛋白的大小和类型以及血清游离轻链检测来确定MGUS预后的新风险分层系统。
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