药物相互作用给每个人的一个教训。

A lesson for everyone in drug-drug interactions.

作者信息

Akram Kamran, Rao Swapna, Parker Miriam

出版信息

Int J Cardiol. 2007 May 16;118(1):e19-20. doi: 10.1016/j.ijcard.2006.11.235. Epub 2007 Mar 21.

DOI:10.1016/j.ijcard.2006.11.235

Abstract

An 84-year-old man was admitted to the hospital for severe rhabdomyolysis induced by drug-drug interactions between simvastatin and ketoconazole and he recovered completely. Guidelines are suggesting lower goals for low density cholesterol leading to increased statin use. As the population is aging and treated with multiple medications for other co-morbidities, it is imperative for physician to be aware of potential fatal drug-drug interactions, in our case statins, and look for alternatives.

摘要

一名84岁男性因辛伐他汀与酮康唑之间的药物相互作用导致严重横纹肌溶解症入院，后完全康复。指南建议降低低密度胆固醇目标，这导致他汀类药物使用增加。随着人口老龄化以及因其他合并症而使用多种药物治疗，医生必须意识到潜在的致命药物相互作用，在我们这个病例中是他汀类药物，并寻找替代药物。