Roques Sébastien, Lytrivi Maria, Rusu Daniel, Devriendt Jacques, De Bels David
Intensive Care Department, Brugmann University Hospital, Brussels, Belgium.
Drug Metabol Drug Interact. 2011;26(2):79-80. doi: 10.1515/DMDI.2011.106. Epub 2011 Apr 18.
We present the case of an 82-year-old man admitted to our hospital for muscle weakness. He was under simvastatin 20 mg per day and was given pulse itraconazole therapy 8 days before the onset of symptoms for onychomycosis. He developed severe rhabdomyolysis inducing an acute renal failure necessitating renal replacement therapy. He eventually fully recovered. Given the possible concurrent use of simvastatin and itraconazole, awareness of this potential interaction is clinically important.
我们报告一例82岁男性因肌肉无力入院。他每天服用20毫克辛伐他汀，在出现症状前8天因甲癣接受了脉冲伊曲康唑治疗。他发生了严重的横纹肌溶解，导致急性肾衰竭，需要进行肾脏替代治疗。他最终完全康复。鉴于辛伐他汀和伊曲康唑可能同时使用，认识到这种潜在相互作用在临床上很重要。
