Klekot A A
Vinnitsa National Medical University.
Bull Exp Biol Med. 2006 Aug;142(2):209-11. doi: 10.1007/s10517-006-0329-3.
Antiarrhythmic activity of a membrane-protecting agent Sal'magin was studied in rats with aconitine-induced cardiac arrhythmias. The test preparation was more potent than amiodaron in producing the antiarrhythmic effect in rats with Na(+)-induced cardiac arrhythmias. The absence of side effects, low toxicity, and high animal survival rate under experimental conditions suggest that Sal'magin holds much promise as an antiarrhythmic drug in clinical practice.
在乌头碱诱发心律失常的大鼠中研究了膜保护剂沙尔马金的抗心律失常活性。在钠诱导心律失常的大鼠中，受试制剂产生抗心律失常作用的效力比胺碘酮更强。在实验条件下无副作用、低毒性以及高动物存活率表明，沙尔马金在临床实践中作为一种抗心律失常药物很有前景。
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