[The anti-arrhythmia action of low-molecular polyvinylpyrrolidone in experimental arrhythmias].

The experiments on 258 albino rats and on 74 albino mice have established that low molecular polyvinylpyrrolidone (PVP) has antiarrhythmic effects. When administered intravenously on a adrenaline model of arrhythmia, PVP and ethmozine showed a very close activity, but PVP resulted in a lower incidence of mortality and proarrhythmia. The action of PVP was weaker than that of ethmozine when they were used in an aconitine model. Oral PVP acted on aconitine-induced arrhythmia stronger and longer than did ethmozine. It is advisable to study the mechanisms of antiarrhythmic activity of PVP.