蛋白激酶B/Akt亚型在发育和疾病中的生理作用。
Physiological roles of PKB/Akt isoforms in development and disease.
作者信息
Dummler B, Hemmings B A
机构信息
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
出版信息
Biochem Soc Trans. 2007 Apr;35(Pt 2):231-5. doi: 10.1042/BST0350231.
PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBalpha (Akt1), PKBbeta (Akt2) and PKBgamma (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.
蛋白激酶B（PKB，也称为Akt）是一种丝氨酸/苏氨酸蛋白激酶，在各种信号级联反应中起重要作用，是活化的磷酸肌醇3激酶下游的主要信号转导分子。在哺乳动物细胞中，PKB有三种密切相关的亚型，即PKBα（Akt1）、PKBβ（Akt2）和PKBγ（Akt3）。本综述讨论了我们对这些亚型在脂肪细胞分化、葡萄糖稳态和肿瘤发生调控中的功能的最新认识进展。
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