Naumann M
Medical Faculty, Institute of Experimental Internal Medicine, Otto-von-Guericke-University, Leipziger Strasse, 39120 Magdeburg, Germany.
Biochem Soc Trans. 2007 Apr;35(Pt 2):267-9. doi: 10.1042/BST0350267.
One of the important cellular factors involved in the regulation of the host antimicrobial response is the immediate early response transcription factor NF-kappaB (nuclear factor kappaB). Human pathogenic micro-organisms trigger cellular signal transduction pathways that induce NF-kappaB, but pathogens have also found ways to overcome the inflammatory response through active manipulation of NF-kappaB regulators. Exploration of the mechanisms that influence NF-kappaB activity could contribute to a better understanding of the molecular pathogenesis of microbial infections and could be important for potential therapeutic intervention that may be relevant in a wide variety of inflammatory diseases.
参与宿主抗菌反应调节的重要细胞因子之一是即刻早期反应转录因子NF-κB（核因子κB）。人类致病微生物触发诱导NF-κB的细胞信号转导途径，但病原体也找到了通过积极操纵NF-κB调节因子来克服炎症反应的方法。探索影响NF-κB活性的机制有助于更好地理解微生物感染的分子发病机制，对于可能与多种炎症性疾病相关的潜在治疗干预可能具有重要意义。
