Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100266, Gainesville, Florida, USA.
Nat Rev Microbiol. 2011 Apr;9(4):291-306. doi: 10.1038/nrmicro2539. Epub 2011 Mar 8.
The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-κB proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-κB signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-κB signalling circuitry to favour the continued survival of the pathogen.
核因子-κB（NF-κB）转录因子家族在宿主对微生物病原体感染的反应中起着核心作用，通过协调先天和获得性的宿主免疫反应。NF-κB 蛋白被来自许多不同细胞受体和传感器的各种信号通路激活。许多成功的病原体已经获得了复杂的机制，通过部署颠覆性蛋白或劫持宿主信号分子来调节 NF-κB 信号通路。在这里，我们描述了病毒和细菌如何精细地控制宿主 NF-κB 信号电路，以有利于病原体的持续生存。
