Hariharan Jaishree, Lamb Geoffrey C, Neuner Joan M
Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
J Gen Intern Med. 2007 Apr;22(4):485-90. doi: 10.1007/s11606-006-0084-1.
The use of opioid medications to manage chronic pain is complex and challenging, especially in primary care settings. Medication contracts are increasingly being used to monitor patient adherence, but little is known about the long-term outcomes of such contracts.
To describe the long-term outcomes of a medication contract agreement for patients receiving opioid medications in a primary care setting.
Retrospective cohort study.
All patients placed on a contract for opioid medication between 1998 and 2003 in an academic General Internal Medicine teaching clinic.
Demographics, diagnoses, opiates prescribed, urine drug screens, and reasons for contract cancellation were recorded. The association of physician contract cancellation with patient factors and medication types were examined using the Chi-square test and multivariate logistic regression.
A total of 330 patients constituting 4% of the clinic population were placed on contracts during the study period. Seventy percent were on indigent care programs. The majority had low back pain (38%) or fibromyalgia (23%). Contracts were discontinued in 37%. Only 17% were cancelled for substance abuse and noncompliance. Twenty percent discontinued contract voluntarily. Urine toxicology screens were obtained in 42% of patients of whom 38% were positive for illicit substances.
Over 60% of patients adhered to the contract agreement for opioids with a median follow-up of 22.5 months. Our experience provides insight into establishing a systematic approach to opioid administration and monitoring in primary care practices. A more structured drug testing strategy is needed to identify nonadherent patients.
使用阿片类药物来管理慢性疼痛是复杂且具有挑战性的,尤其是在初级保健环境中。药物合同越来越多地被用于监测患者的依从性,但对于此类合同的长期结果知之甚少。
描述在初级保健环境中接受阿片类药物治疗的患者的药物合同协议的长期结果。
回顾性队列研究。
1998年至2003年期间在一所学术性普通内科教学诊所签订阿片类药物合同的所有患者。
记录人口统计学信息、诊断结果、开具的阿片类药物、尿液药物筛查结果以及合同取消的原因。使用卡方检验和多因素逻辑回归分析医生取消合同与患者因素及药物类型之间的关联。
在研究期间,共有330名患者(占诊所患者总数的4%)签订了合同。70%的患者参加了贫困护理项目。大多数患者患有腰痛(38%)或纤维肌痛(23%)。37%的合同被终止。只有17%的合同因药物滥用和不依从而被取消。20%的患者自愿终止合同。42%的患者接受了尿液毒理学筛查,其中38%的患者非法物质检测呈阳性。
超过60%的患者在中位随访22.5个月期间遵守了阿片类药物合同协议。我们的经验为在初级保健实践中建立阿片类药物给药和监测的系统方法提供了见解。需要一种更结构化的药物检测策略来识别不依从的患者。