Wiseman Luke K, Lynch Mary E
Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
Can J Pain. 2018 Feb 8;2(1):37-47. doi: 10.1080/24740527.2018.1425980. eCollection 2018.
A recent systematic review found few studies that assessed the value of urinary drug screening (UDS) in the management of chronic pain. The Pain Management Unit in Halifax, Nova Scotia, has recently implemented tandem mass spectrometry (TMS) UDS for all new patients.
To study the prevalence of unexpected TMS UDS results at a hospital-based chronic pain center, to assess which drugs are most likely to contribute to an unexpected result and to assess the clinical utilization of unexpected results by pain physicians.
From June 2014 to June 2016, a total of 664 patients with chronic non-cancer pain (CNCP) were seen for initial consult. Charts were reviewed and used to create a database containing sex, age, UDS result, physician, and medication/illicit drug history. For all unexpected UDS results, an interview was conducted with the treating physician to determine its clinical implications.
For the general pain specialists, the overall percentage of patients with an unexpected UDS result was 16.67%. Excluding codeine, at most 4.47% of patients tested unexpectedly positive for a strong opioid. Although eight out of nine physicians found UDS helpful in general, only 29.58% of unexpected results were helpful in the management of their patients and directly influenced their care.
The prevalence of an unexpected UDS result in patients with CNCP is significant. Most physicians agree that UDS is helpful but in only a limited number of cases did the unexpected result provide helpful information that significantly influenced patient care.
最近一项系统评价发现,评估尿液药物筛查(UDS)在慢性疼痛管理中的价值的研究很少。新斯科舍省哈利法克斯的疼痛管理部门最近对所有新患者实施了串联质谱(TMS)UDS。
研究一家医院慢性疼痛中心意外TMS UDS结果的发生率,评估哪些药物最有可能导致意外结果,并评估疼痛科医生对意外结果的临床应用情况。
2014年6月至2016年6月,共有664例慢性非癌性疼痛(CNCP)患者前来进行初次咨询。查阅病历并用于创建一个数据库,其中包含性别、年龄、UDS结果、医生以及用药/非法药物史。对于所有意外的UDS结果,与主治医生进行访谈以确定其临床意义。
对于普通疼痛专科医生而言,UDS结果意外的患者总体比例为16.67%。排除可待因,最多4.47%的患者检测出强阿片类药物意外呈阳性。尽管九名医生中有八名总体上认为UDS有帮助,但只有29.58%的意外结果有助于管理他们的患者并直接影响他们的治疗。
CNCP患者中UDS结果意外的发生率很高。大多数医生都认为UDS有帮助,但只有少数情况下意外结果提供了有助于显著影响患者治疗的有用信息。