World Health Organ Tech Rep Ser. 2006(942):i, 1-21, 23-4 passim.
This report presents the recommendations of a WHO Expert Committee responsible for reviewing information on dependence-producing drugs to assess the need for their international control. The first part of the report contains a summary of the Committee's evaluations of seven substances (dronabinol, oripavine, buprenorphine, butorphanol, ketamine, khat and zopiclone). The report also discusses the substances that were pre-reviewed (gamma-hydroxybutyric acid and tramadol) and recommended gamma-hydroxybutyric acid for critical review at a future meeting. Two substances (gamma-butyrolactone and 1,4-butanediol) were identified for future pre-review). The second part of the report discusses the guidelines for the WHO review of dependence-producing psychoactive substances for international control. It includes sections on amending the current guidelines, interpretation of specific aspects of the guidelines and access to information necessary for the evaluation of substances. The final section considers other matters including activities of the EMCCDA, the use of pharmacovigilance data, promotion of education and information on the appropriate use of psychoactive drugs and the impact of international control on medical availability of substances.
本报告介绍了世界卫生组织一个专家委员会的建议，该委员会负责审查有关致依赖性药物的信息，以评估对其进行国际管制的必要性。报告第一部分总结了委员会对七种物质（屈大麻酚、阿片全碱、丁丙诺啡、布托啡诺、氯胺酮、巧茶和佐匹克隆）的评估。报告还讨论了预先审查的物质（γ-羟基丁酸和曲马多），并建议在未来会议上对γ-羟基丁酸进行严格审查。确定了两种物质（γ-丁内酯和1,4-丁二醇）以供未来进行预先审查。报告第二部分讨论了世界卫生组织对用于国际管制的致依赖性精神活性物质进行审查的指导方针。其中包括修订现行指导方针、对指导方针具体方面的解释以及获取评估物质所需信息等章节。最后一部分审议了其他事项，包括欧洲药物和药物成瘾监测中心的活动、药物警戒数据的使用、促进关于精神活性药物适当使用的教育和信息，以及国际管制对物质医疗可及性的影响。
