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食品中某些兽药残留的评估。联合国粮农组织/世界卫生组织食品添加剂联合专家委员会第六十六次报告。

Evaluation of certain veterinary drug residues in food. Sixty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives.

出版信息

World Health Organ Tech Rep Ser. 2006(939):1-80, backcover.

Abstract

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of JECFA, including compounds without an ADI or MRL; recommendations on principles and methods in derivation of MRLs, including a new procedure for estimating chronic dietary intakes; the use of a spreadsheet-based procedure for the statistical evaluation of residue depletion data; a revised approach for the derivation of microbiological ADIs; and the Committee's review of and comments on documents provided by the Codex Committee on Residues of Veterinary Drugs. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (colistin, erythromycin, flumequine), two production aids (melengestrol acetate, ractopamine hydrochloride), an insecticide (trichlorfon (metrifonate)) and an anthelminthic (triclabendazole). In addition, the attempt by the Committee to use tylosin as an example to investigate if evaluations are possible based on published data in the absence of data submissions from sponsors is described. Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.

摘要

本报告阐述了粮农组织/世卫组织联合专家委员会的结论,该委员会旨在评估某些兽药在食品中的残留安全性,并就此类残留的食品最高限量提出建议。报告的第一部分审议了在食品添加剂联合专家委员会职权范围内评估兽药的一般原则,包括无每日允许摄入量(ADI)或最高残留限量(MRL)的化合物;关于制定最高残留限量的原则和方法的建议,包括估算慢性膳食摄入量的新程序;使用基于电子表格的程序对残留消除数据进行统计评估;制定微生物每日允许摄入量的修订方法;以及委员会对兽药残留法典委员会提供文件的审查和评论。以下是委员会对多种兽药的毒理学和残留数据评估的摘要:三种抗菌剂(黏菌素、红霉素、氟甲喹)、两种生产助剂(醋酸美仑孕酮、盐酸莱克多巴胺)、一种杀虫剂(敌百虫(美曲膦酯))和一种驱虫药(三氯苯达唑)。此外,还介绍了委员会以泰乐菌素为例,在未收到申办方数据提交的情况下,尝试根据已发表数据进行评估的情况。报告附录为委员会对这些药物的建议摘要,包括每日允许摄入量和提议的最高残留限量。

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