幽门螺杆菌与慢性胆囊炎有关。
H pylori are associated with chronic cholecystitis.
作者信息
Chen Dong-Feng, Hu Lu, Yi Ping, Liu Wei-Wen, Fang Dian-Chun, Cao Hong
机构信息
Department of Gastroenterology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
出版信息
World J Gastroenterol. 2007 Feb 21;13(7):1119-22. doi: 10.3748/wjg.v13.i7.1119.
AIM
To study whether H pylori are associated with chronic cholecystitis.
METHODS
The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylori-negative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 (IL-1, 6 and 8) were detected by radioimmunoassay.
RESULTS
Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H pylori-infected cholecystitis group than those in H pylori-negative cholecystitis group and control group.
CONCLUSION
H pylori infection may be related to cholecystitis.
目的
研究幽门螺杆菌是否与慢性胆囊炎有关。
方法
将受试者分为三组：幽门螺杆菌感染胆囊炎组、幽门螺杆菌阴性胆囊炎组和对照组。通过光学显微镜和电子显微镜观察胆囊的病理变化，采用放射免疫分析法检测白细胞介素-1、6和8（IL-1、6和8）水平。
结果
在幽门螺杆菌定植区域发现了包括变性、坏死、炎性细胞浸润在内的慢性胆囊炎组织学证据。幽门螺杆菌感染胆囊炎组胆囊黏膜匀浆中IL-1、6和8水平显著高于幽门螺杆菌阴性胆囊炎组和对照组。
结论
幽门螺杆菌感染可能与胆囊炎有关。
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