Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China.
Helicobacter. 2018 Feb;23(1). doi: 10.1111/hel.12457. Epub 2017 Dec 20.
Helicobacter pylori is coexisted with various diseases, including chronic gastritis, ulcer, and gastric cancer. Besides, chronic cholecystitis and cholelithiasis are extremely widespread over the world, which are considered as high health-care cost burdens of digestive diseases. Epidemiologic evidence on Helicobacter pylori infection in gallbladder increasing the risk of biliary diseases has been contradictory.
Conduct a meta-analysis of overall studies and investigate an association between Helicobacter pylori infection of the gallbladder with chronic cholecystitis/cholelithiasis.
We used PubMed, EMBASE, and Cochrane library databases to identify all published studies before August 2017. Pooled odds ratios (OR) and corresponding 95% confidence intervals (CIs) were obtained using the random effects model. Heterogeneity, sensitivity, and stratified analyses were also performed.
Eighteen studies involving 1544 participants and 1061 biliary cases with chronic cholecystitis/cholelithiasis were included. Helicobacter pylori infection of the gallbladder was significantly associated with an increased risk of chronic cholecystitis and cholecystitis (OR = 3.022; 95% CI, 1.897-4.815; I = 20.1%). In addition, country-based subgroup analysis also showed a positive association between Helicobacter pylori positivity and chronic cholecystitis/cholelithiasis risk. The ORs (95% CIs) for Asian and non-Asian region studies were 3.75 (1.83-7.71) and 2.25 (1.29-3.89), respectively.
This meta-analysis suggests that infection of the gallbladder with Helicobacter pylori is closely related to an increased risk of chronic cholecystitis and cholelithiasis.
幽门螺杆菌与多种疾病共存，包括慢性胃炎、溃疡和胃癌。此外，慢性胆囊炎和胆石症在全球极为普遍，被认为是消化系统疾病中高医疗保健费用的负担。关于胆囊内幽门螺杆菌感染增加胆系疾病风险的流行病学证据存在矛盾。
对所有研究进行荟萃分析，探讨胆囊内幽门螺杆菌感染与慢性胆囊炎/胆石症之间的关系。
我们使用 PubMed、EMBASE 和 Cochrane 图书馆数据库检索截至 2017 年 8 月之前发表的所有研究。使用随机效应模型获得汇总优势比（OR）和相应的 95%置信区间（CI）。还进行了异质性、敏感性和分层分析。
纳入了 18 项研究，涉及 1544 名参与者和 1061 例慢性胆囊炎/胆石症的胆系病例。胆囊内幽门螺杆菌感染与慢性胆囊炎和胆囊炎的发生风险增加显著相关（OR=3.022；95%CI，1.897-4.815；I²=20.1%）。此外，基于国家的亚组分析也显示了胆囊内幽门螺杆菌阳性与慢性胆囊炎/胆石症风险之间的正相关关系。亚洲和非亚洲地区研究的 OR（95%CI）分别为 3.75（1.83-7.71）和 2.25（1.29-3.89）。
这项荟萃分析表明，胆囊内幽门螺杆菌感染与慢性胆囊炎和胆石症的发生风险密切相关。
