Sumaya C V
J Clin Microbiol. 1975 Dec;2(6):520-23. doi: 10.1128/jcm.2.6.520-523.1975.
Studies by others have demonstrated a leukocyte-transforming agent(s) (LTA) in the oropharyngeal secretions of a significant number of individuals with Epstein-Barr virus-associated infectious mononucleosis, cancer, and, to a lesser extent, an outpatient population. This present study determines by systematic sampling the prevalence of LTA in 27 families of a semirural community. Throat swab inoculums from three of 54 adults and none of 44 children induced transformation of umbilical cord lymphocytes. Complement-dependent Epstein-Barr virus nuclear antigen was detected in two of the three transformed cell cultures. The three LTA-positive individuals were characterized by the absence of serologic evidence of a recent Epstein-Barr virus infection and the lack of elevated antibodies against the viral capsid antigen of Epstein-Barr virus.
其他研究表明，在大量患有爱泼斯坦-巴尔病毒相关传染性单核细胞增多症、癌症的个体以及（程度较轻的）门诊患者的口咽分泌物中存在一种白细胞转化因子（LTA）。本研究通过系统抽样确定了一个半农村社区27个家庭中LTA的流行情况。54名成年人中有3人以及44名儿童中无人的咽拭子接种物能诱导脐带淋巴细胞转化。在三种转化的细胞培养物中有两种检测到了补体依赖性爱泼斯坦-巴尔病毒核抗原。这三名LTA阳性个体的特征是缺乏近期爱泼斯坦-巴尔病毒感染的血清学证据，且针对爱泼斯坦-巴尔病毒病毒衣壳抗原的抗体未升高。
