Niederman J C, Miller G, Pearson H A, Pagano J S, Dowaliby J M
N Engl J Med. 1976 Jun 17;294(25):1355-9. doi: 10.1056/NEJM197606172942501.
In an examination of excretion patterns of Epstein-Barr virus in 104 throat washings from 20 patients with infectious mononucleosis we found that three persons regularly shed virus from the second week through the third month after onset; 15 demonstrated intermittent excretion over three months, and in two cases, no virus was detected. In oral secretions, the virus appeared to be located extracellularly. Transforming activity was demonstrated in aliquots after centrifugation and filtration, in a sample in which cells were disrupted before filtration, and in specimens after two years' storage. Multiple oropharyngeal sites were examined for presence of the virus. In one patient, virus was regularly demonstrated in throat washings and saliva; swabs from Stensen's duct orifices yielded virus in three of four cases. Demonstration of virus in these oropharyngeal specimens explains increased transmissibility in age groups in which salivary exchange is high.
在对20例传染性单核细胞增多症患者的104份咽洗液进行的爱泼斯坦-巴尔病毒排泄模式检查中，我们发现，3人在发病后第二周直至第三个月持续排出病毒；15人在三个月内间歇性排出病毒，2例未检测到病毒。在口腔分泌物中，病毒似乎位于细胞外。在离心和过滤后的等分试样中、在过滤前细胞被破坏的样本中以及在储存两年后的标本中均显示出转化活性。对多个口咽部位进行了病毒检测。在1例患者中，咽洗液和唾液中经常检测到病毒；来自斯滕森导管口的拭子在4例中有3例检测到病毒。在这些口咽标本中检测到病毒，解释了在唾液交换频繁的年龄组中传染性增加的原因。
