Tokumura Fumio, Homma Takeyasu, Tomiya Toshiki, Kobayashi Yuko, Matsuda Tetsuaki
TDS Research Laboratory, Nichiban Co, Ltd, Hikada, Japan.
Skin Res Technol. 2007 May;13(2):211-6. doi: 10.1111/j.1600-0846.2007.00211.x.
BACKGROUND/PURPOSE: The use of soft adhesives in the manufacture of pressure-sensitive adhesive tapes has recently increased. The dermal peeling force of adhesive tapes with soft adhesives was studied.
Four kinds of adhesive tapes with adhesives of different softness were made, by adding varying amounts of isopropyl myristate as a softener. The tapes were applied on the flexor side of the forearm of six healthy male volunteers. The dermal peeling force, the amount of stripped corneocytes, the level of pain when the tapes were removed and the degree of penetration of adhesives into the sulcus cutis (skin furrows) were evaluated at 1 and 24 h after application of the tapes. Furthermore, a skin model panel (a sulcus cutis and crista cutis model panel) and a crista cutis model panel were constructed from a general stainless-steel panel, and the peeling force of the tapes against the model panels was measured.
As the softness of adhesives increased, the peeling force against a general stainless-steel panel with a flat surface decreased, although the peeling force against human skin did not significantly change. The amount of stripped corneocytes on the removed tapes and the level of pain when the tapes were removed decreased with the increase in softness of the adhesives. These results suggest that adhesive tapes with soft adhesives that contain isopropyl myristate as a softener are suitable for the skin. Furthermore, the degree of penetration of adhesive into the sulcus cutis increased as the softness of adhesives increased. Upon evaluation of the peeling force against the model panels, as the softness of adhesives increased, there was a slight decrease in the peeling force against the skin model panel, while there was a remarkable decrease in the peeling force against the crista cutis model panel. These results suggest that the lack of change in the dermal peeling force as the softness of adhesives increased was caused by penetration of soft adhesive into the sulcus cutis, and that the decrease in the amount of stripped corneocytes was caused by a decrease in the peeling force against the crista cutis, which consists of corneocytes mainly removed by the tapes.
背景/目的：近年来，软质胶粘剂在压敏胶带制造中的应用有所增加。本研究对含软质胶粘剂的胶带的皮肤剥离力进行了研究。
通过添加不同量的肉豆蔻酸异丙酯作为软化剂，制备了四种具有不同柔软度胶粘剂的胶带。将这些胶带贴于6名健康男性志愿者前臂的屈侧。在贴胶带后1小时和24小时，评估皮肤剥离力、剥离角质形成细胞的数量、去除胶带时的疼痛程度以及胶粘剂渗入皮肤沟（皮肤皱纹）的程度。此外，由普通不锈钢板构建了一个皮肤模型板（皮肤沟和皮肤嵴模型板）和一个皮肤嵴模型板，并测量了胶带对模型板的剥离力。
随着胶粘剂柔软度的增加，其对表面平整的普通不锈钢板的剥离力降低，而对人体皮肤的剥离力无显著变化。去除的胶带上剥离的角质形成细胞数量以及去除胶带时的疼痛程度随着胶粘剂柔软度的增加而降低。这些结果表明，含有肉豆蔻酸异丙酯作为软化剂的软质胶粘剂胶带适用于皮肤。此外，随着胶粘剂柔软度的增加，胶粘剂渗入皮肤沟的程度增加。在评估对模型板的剥离力时，随着胶粘剂柔软度的增加，对皮肤模型板的剥离力略有下降，而对皮肤嵴模型板的剥离力则显著下降。这些结果表明，随着胶粘剂柔软度增加皮肤剥离力未发生变化是由于软质胶粘剂渗入皮肤沟所致，而剥离的角质形成细胞数量减少是由于对主要由胶带去除的角质形成细胞组成的皮肤嵴的剥离力降低所致。
