Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18803-8. doi: 10.1073/pnas.1216071109. Epub 2012 Oct 29.
Medical tape that provides secure fixation of life-sustaining and -monitoring devices with quick, easy, damage-free removal represents a longstanding unmet medical need in neonatal care. During removal of current medical tapes, crack propagation occurs at the adhesive-skin interface, which is also the interface responsible for device fixation. By designing quick-release medical tape to undergo crack propagation between the backing and adhesive layers, we decouple removal and device fixation, enabling dual functionality. We created an ordered adhesive/antiadhesive composite intermediary layer between the medical tape backing and adhesive for which we achieve tunable peel removal force, while maintaining high shear adhesion to secure medical devices. We elucidate the relationship between the spatial ordering of adhesive and antiadhesive regions to create a fully tunable system that achieves strong device fixation and quick, easy, damage-free device removal. We also described ways of neutralizing the residual adhesive on the skin and have observed that thick continuous films of adhesive are easier to remove than the thin islands associated with residual adhesive left by current medical tapes.
医用胶带在为维持生命和监测生命的设备提供可靠固定的同时，还能快速、轻松、无损地移除，这在新生儿护理中是一项长期未得到满足的医疗需求。在移除当前的医用胶带时，裂纹会在胶黏剂-皮肤界面处扩展，而该界面也是负责设备固定的界面。通过设计可在背衬和胶黏剂层之间发生裂纹扩展的快速释放医用胶带，我们可以将移除和设备固定解耦，实现双重功能。我们在医用胶带背衬和胶黏剂之间创建了一个有序的胶黏剂/抗胶黏剂复合中间层，我们实现了可调节的剥离去除力，同时保持对医疗设备的高剪切附着力，以确保其安全。我们阐明了胶黏剂和抗胶黏剂区域的空间排列关系，以创建一个完全可调的系统，实现对设备的强力固定以及快速、轻松、无损地移除设备。我们还描述了中和皮肤残留胶黏剂的方法，并观察到与当前医用胶带残留胶黏剂相关的薄岛状残留相比，厚连续胶黏剂薄膜更容易去除。
