Bozzo Andrea, Soñez Carlos Alberto, Mugnaini María Teresa, Pastorino Isabel Cecilia, Rolando Alicia Nélida, Romanini María Cristina, Gauna Héctor Fernando
Cátedra de Biología Celular y Embriologia General, Facultad de Agronomia y Veterinaria, Universidad Nacional de Rio Cuarto, (CP. X5804BYA) Rio Cuarto, Córdoba, Argentina.
Biocell. 2006 Dec;30(3):439-45.
Chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. The apoptotic index did not present significant differences between the adrenal cortex areas of control and experimental rats in any of the three ages studied. The day of gestation influenced significantly on the apoptotic index in both groups. This index increased as gestation progressed. It may be concluded that chronic stress by immobilization might induce the increase of apoptotic index in adrenal cortex as gestation progresses which might be related variations of plasmatic corticosterone and prolactin, and to the decrease of specific growth factors. On the other hand, it might be concluded that each zone of adrenal cortex behaves independently in regards to apoptosis and cellular proliferation via paracrine and/or autocrine regulatory mechanisms without being affected by other zones.
孕期固定所致的慢性应激可改变维持肾上腺内环境稳定的多种机制。本研究的目的是量化妊娠中期肾上腺皮质的凋亡指数，并通过电子显微镜观察其细胞学特征。在所研究的三个年龄段中，对照组和实验组大鼠肾上腺皮质区域的凋亡指数均无显著差异。妊娠日数对两组的凋亡指数均有显著影响。随着妊娠进展，该指数升高。可以得出结论，孕期固定所致的慢性应激可能会随着妊娠进展导致肾上腺皮质凋亡指数增加，这可能与血浆皮质酮和催乳素的变化以及特定生长因子的减少有关。另一方面，可以得出结论，肾上腺皮质的每个区域在凋亡和细胞增殖方面通过旁分泌和/或自分泌调节机制独立发挥作用，不受其他区域的影响。
