Buzueva I I, Shmerling M D, Filiushina E E, Markel' A L, Iakobson G S
Laboratory of Electron Microscopy, Siberian Section of Russian Academy of Medical Sciences, Novosibirsk.
Morfologiia. 1998;113(2):84-8.
Comparative morphometric examination of adrenal cortex was carried out in 3 wks HNCAI rats with inherited stress induced arterial hypertension and normotensive Wistar rats. Relative adrenal mass, volume of cortex and its glomerular zone in HNCAI rats exceeds appropriate values in Wistar rats. Increase of adrenocorticocytes due to hyperplasia of their ultrastructural components was found. In hypertensive rats adrenocorticocyte numerical density increase due to their hyperplasia was found in adrenal fasciculate zone in contrast to glomerular one. These structural organization peculiarities in 3 wks hypertensive rat adrenal cortex reflect their elevated functional activity and may determine genetically programmed increased organism responsiveness to stress that consequently provides the grounds for the hypertensive status formation in this rat line.
对遗传性应激诱导性动脉高血压的3周龄HNCAI大鼠和血压正常的Wistar大鼠的肾上腺皮质进行了形态计量学比较检查。HNCAI大鼠的相对肾上腺质量、皮质及其球状带体积超过了Wistar大鼠的相应值。发现肾上腺皮质细胞由于其超微结构成分的增生而增加。与球状带相比，在高血压大鼠的肾上腺束状带中发现肾上腺皮质细胞数量密度因增生而增加。3周龄高血压大鼠肾上腺皮质的这些结构组织特点反映了它们功能活动的增强，可能决定了机体对压力的遗传程序化反应增加，从而为该大鼠品系高血压状态的形成提供了依据。
