肝细胞癌患者淋巴结转移的放射治疗：回顾性研究
Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: retrospective study.
作者信息
Yamashita Hideomi, Nakagawa Keiichi, Shiraishi Kenshiro, Tago Masao, Igaki Hiroshi, Nakamura Naoki, Sasano Nakashi, Siina Shuichiro, Omata Masao, Ohtomo Kuni
机构信息
Department of Radiology, University of Tokyo Hospital, Tokyo, Japan.
出版信息
J Gastroenterol Hepatol. 2007 Apr;22(4):523-7. doi: 10.1111/j.1440-1746.2006.04450.x.
AIM
This study was conducted to evaluate the effect of external radiation therapy on lymph node metastases from hepatocellular carcinoma (HCC).
METHODS
A total 28 patients with cytopathologically proven HCC were subjected to radiation therapy over a 5-year period, and treatment was continued in all cases. All patients underwent irradiation with a total dose ranging between 46 and 60 Gy in daily 2.0-Gy fractions, five times a week.
RESULTS
Among the metastatic lesions treated, 18 (64%) and five (18%) patients achieved partial responses and complete responses, respectively. The 1- and 2-year overall survival rates and the median survival time were 53% and 33%, respectively, and 13 months in patients given external beam radiation therapy (EBRT) for a non-palliative, near-cure intent (n = 21).
CONCLUSIONS
Although lymph node metastasis from HCC is sensitive to EBRT, the intent of EBRT should be limited to palliation. For palliative purposes, it is useful in treatment with 50 Gy in 25 fractions for these patients.
目的
本研究旨在评估外照射放疗对肝细胞癌（HCC）淋巴结转移的疗效。
方法
在5年期间，对总共28例经细胞病理学证实为HCC的患者进行放疗，所有病例均持续治疗。所有患者接受的总剂量在46至60 Gy之间，每日分2.0 Gy照射，每周5次。
结果
在接受治疗的转移病灶中，分别有18例（64%）和5例（18%）患者获得部分缓解和完全缓解。对于接受非姑息性、接近治愈目的外照射放疗（EBRT）的患者（n = 21），1年和2年总生存率及中位生存时间分别为53%和33%，以及13个月。
结论
尽管HCC淋巴结转移对外照射放疗敏感，但外照射放疗的目的应限于姑息治疗。对于姑息治疗目的，对这些患者采用25次分割给予50 Gy的治疗是有效的。
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