Wotherspoon A C, Doglioni C, Isaacson P G
Department of Histopathology, University College, Middlesex School of Medicine, London, UK.
Histopathology. 1992 Jan;20(1):29-34. doi: 10.1111/j.1365-2559.1992.tb00912.x.
Gastrectomy specimens from five patients following gastroscopic biopsies which showed low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) were examined by serially sectioning and paraffin wax embedding using a 'swiss roll' technique. This procedure allowed the construction of a map of the specimen on which the distribution of the lymphoma could be plotted. In each case confluent lymphoma was identified. In addition small foci of lymphoma consisting of 1-4 lymphoid follicles surrounded by neoplastic centrocyte-like cells were seen. The positions of these 'micro-lymphomas' were plotted on the gastrectomy maps, showing multiple foci distributed throughout the gastric mucosa. The identification of these microscopic lesions may explain the development of local relapse, often after a long disease-free interval, in patients with gastric MALT lymphoma treated by partial gastrectomy where excision appears to have been complete. Patients treated in this way should, therefore, be followed-up indefinitely, with regular endoscopy and gastric biopsy, in order to identify early local disease relapse.
对5例经胃镜活检显示黏膜相关淋巴组织（MALT）低度B细胞淋巴瘤的患者的胃切除标本，采用“瑞士卷”技术进行连续切片和石蜡包埋检查。该操作可以构建标本图谱，在上面绘制淋巴瘤的分布情况。在每例中均发现融合性淋巴瘤。此外，还可见到由1 - 4个淋巴滤泡组成、被肿瘤性中心细胞样细胞包围的小淋巴瘤病灶。将这些“微淋巴瘤”的位置标绘在胃切除标本图谱上，显示多个病灶分布于整个胃黏膜。这些微小病变的发现或许可以解释部分胃切除术后看似切除彻底的胃MALT淋巴瘤患者为何常常在较长的无病间期后出现局部复发。因此，接受这种治疗的患者应无限期随访，定期进行内镜检查和胃活检，以便早期发现局部疾病复发。
