Stecco Alessandro, Buemi Francesco, Quagliozzi Martina, Lombardi Mariangela, Santagostino Alberto, Sacchetti Gian Mauro, Carriero Alessandro
Radiology Department, "Maggiore della Carità" University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, Italy.
Oncohaematology Department, Sant'Andrea Hospital, Corso Mario Abbiate 21, 13100 Vercelli, Italy.
Gastroenterol Res Pract. 2015;2015:104794. doi: 10.1155/2015/104794. Epub 2015 Dec 22.
Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of (18)F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma. Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent (18)F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis. Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniques (p = 0.05). The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95-0.99) between the two MRI readers and 0.87 (0.82-0.92) between the two methods. Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to (18)F-FDG-PET/CT in staging patients with gastrointestinal lymphoma.
背景。本研究的目的是比较全身磁共振成像弥散加权序列（WB-DW-MRI）与18F-FDG-PET/CT在原发性胃肠道淋巴瘤患者分期中的准确性。方法。这项回顾性研究纳入了17例未经治疗的原发性腹部胃肠道淋巴瘤患者。所有患者均接受了18F-FDG-PET/CT和WB-DW-MRI检查。组织病理学结果或至少6个月的临床及影像学随访为金标准。采用Musshoff改良的Ann Arbor系统进行分期，并对每个淋巴结的诊断准确性进行评估。结果。WB-DW-MRI的敏感性为100%，特异性为96.3%，阳性预测值和阴性预测值分别为96.1%和100%。PET/CT的敏感性、特异性、阳性预测值和阴性预测值分别为95.9%、100%、100%和96.4%。两种技术之间无统计学显著差异（p = 0.05）。两位MRI阅片者之间的加权kappa一致性统计量及95%置信区间为0.97（0.95 - 0.99），两种方法之间为0.87（0.82 - 0.92）。结论。在胃肠道淋巴瘤患者分期方面，WB-DW-MRI似乎与18F-FDG-PET/CT具有相当的诊断价值。
