心脏G蛋白偶联受体：健康心脏与衰竭心脏中的G蛋白偶联受体信号传导
Cardiac GPCRs: GPCR signaling in healthy and failing hearts.
作者信息
Salazar Natasha C, Chen Juhsien, Rockman Howard A
机构信息
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Biochim Biophys Acta. 2007 Apr;1768(4):1006-18. doi: 10.1016/j.bbamem.2007.02.010. Epub 2007 Feb 20.
Abstract
G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.
摘要
G蛋白偶联受体（GPCRs）与人类心脏病密切相关，使其成为心脏药物治疗的重要靶点。最常研究且临床上作为靶点的心脏GPCRs包括肾上腺素能受体、血管紧张素受体、内皮素受体和腺苷受体。针对这些GPCRs复杂且相互整合的信号通路的治疗方案对于理解和改善心脏病至关重要。本综述的重点是突出最常研究且临床上作为靶点的心脏GPCRs，着重介绍它们在心脏病中涉及的共同信号成分。
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