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角膜炎、鱼鳞病和耳聋(KID)综合征:慢性口服酮康唑治疗管理

Keratitis, ichthyosis, and deafness (KID) syndrome: management with chronic oral ketoconazole therapy.

作者信息

Hazen P G, Walker A E, Stewart J J, Carney J F, Engstrom C W, Turgeon K L

机构信息

Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

出版信息

Int J Dermatol. 1992 Jan;31(1):58-9. doi: 10.1111/j.1365-4362.1992.tb03524.x.

DOI:10.1111/j.1365-4362.1992.tb03524.x
PMID:1737693
Abstract

Extensive cutaneous mycoses have been described in patients with the keratitis, ichthyosis, and deafness (KID) syndrome. We present a case occurring in a 48-year-old woman where improvement in the ichthyosiform dermatosis, stabilization of her ocular disease, and apparent partial prevention of further cutaneous malignancies occurred in association with ketoconazole therapy.

摘要

广泛的皮肤真菌病已在患有角膜炎、鱼鳞病和耳聋(KID)综合征的患者中被描述。我们报告一例发生在一名48岁女性身上的病例,在酮康唑治疗期间,鱼鳞癣样皮肤病有所改善,眼部疾病得到稳定,并且明显部分预防了进一步的皮肤恶性肿瘤。

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引用本文的文献

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Suspect dyskeratotic neoformations in a 7-year-old child with keratitis-ichthyosis-deafness syndrome: diagnostic, surgical and wound care management.一名患有角膜炎-鱼鳞病-耳聋综合征的7岁儿童疑似存在异常角化性新生物:诊断、手术及伤口护理管理
Dermatol Reports. 2024 Apr 16;16(4):9953. doi: 10.4081/dr.2024.9953. eCollection 2024 Nov 21.
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Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome.由于突变 connexin26 导致的异常半通道活性在 KID 综合征发病机制中的作用。
Sci Rep. 2018 Aug 27;8(1):12824. doi: 10.1038/s41598-018-30757-3.
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Connexin 26 (GJB2) mutation in an Argentinean patient with keratitis-ichthyosis-deafness (KID) syndrome: a case report.
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BMC Med Genet. 2016 May 4;17(1):37. doi: 10.1186/s12881-016-0298-y.
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Current perspectives on ophthalmic mycoses.眼部真菌病的当前观点
Clin Microbiol Rev. 2003 Oct;16(4):730-97. doi: 10.1128/CMR.16.4.730-797.2003.