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先天性鱼鳞病伴耳聋和角膜炎中的鳞状细胞癌。病例报告及文献综述。

Squamous cell carcinoma in congenital ichthyosis with deafness and keratitis. A case report and review of the literature.

作者信息

Madariaga J, Fromowitz F, Phillips M, Hoover H C

出版信息

Cancer. 1986 May 15;57(10):2026-9. doi: 10.1002/1097-0142(19860515)57:10<2026::aid-cncr2820571024>3.0.co;2-z.

DOI:10.1002/1097-0142(19860515)57:10<2026::aid-cncr2820571024>3.0.co;2-z
PMID:3955509
Abstract

The first case of invasive squamous cell carcinoma (SCC) arising in the skin of a patient afflicted with keratitis, ichthyosis, and deafness (KID) syndrome is reported. A 35-year-old man, diagnosed as having KID syndrome in early childhood, developed bilateral fungating lesions on his feet. The entire left foot became involved with a multinodular fungating mass which proved to harbor a SCC, necessitating a left below-knee amputation. Although rare, KID syndrome can be associated with SCC of the skin.

摘要

报告了首例发生于角膜炎、鱼鳞病和耳聋(KID)综合征患者皮肤的侵袭性鳞状细胞癌(SCC)。一名35岁男性,自幼被诊断为患有KID综合征,足部出现双侧溃疡性病变。整个左脚受累,形成一个多结节溃疡性肿块,经证实为SCC,因此需要进行左膝下截肢。尽管罕见,但KID综合征可与皮肤SCC相关。

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引用本文的文献

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Connexin hemichannels influence genetically determined inflammatory and hyperproliferative skin diseases.连接蛋白半通道影响基因决定的炎症性和过度增殖性皮肤病。
Pharmacol Res. 2015 Sep;99:337-43. doi: 10.1016/j.phrs.2015.07.015. Epub 2015 Jul 23.