Crowell David H, Sharma Santosh D, Setomd Dexter, Baruffi Gigliola, Dunn-Rankin Peter, Dong Jianfeng
Department of Pediatrics, John A Burns School of Medicine, University of Hawai'i at Manoa, Honolulu HI 96822, USA.
Hawaii Med J. 2007 Jan;66(1):4, 6-8.
Comparative study of racial-ethnic (RE) gestational age (GA) mean birth-weight (MBW) differences for 1968-1994.
Descriptive statistical analyses of 314,633 State of Hawai'i live birth certificates: birthweights of 500-5000 grams, gestational ages 24-42 weeks, and recorded Caucasian, Chinese, Filipino, Hawaiian, Japanese, Samoan, and Other RE parentage. Multiple regression analyses of single infant birth records were performed to adjust birth-weight for selected covariates and assess the independent effects of maternal and paternal RE on MBW.
Samoans consistently displayed significantly the largest MBW whether based on single or mixed RE parentage. After covariate adjustment MBW significantly related to Samoan maternal RE followed by Samoan paternal RE.
A consistent trajectory of larger MBWs across GA span of 24-42 weeks is associated with the Samoan group. Results support the importance of maternal role in determining birth-weight. Additional data for analysis of birth size and cord blood levels of insulin growth factor and research on genetic and epigenetic questions are warranted.
对1968年至1994年不同种族-族裔(RE)的孕周(GA)平均出生体重(MBW)差异进行比较研究。
对314,633份夏威夷州出生证明进行描述性统计分析:出生体重在500 - 5000克之间,孕周为24 - 42周,记录了白人、华人、菲律宾人、夏威夷人、日本人、萨摩亚人和其他种族-族裔的父母情况。对单胎婴儿出生记录进行多元回归分析,以调整选定协变量对出生体重的影响,并评估父母种族-族裔对平均出生体重的独立影响。
无论基于单一种族-族裔还是混合种族-族裔的父母情况,萨摩亚人始终显示出显著最大的平均出生体重。在协变量调整后,平均出生体重与萨摩亚母亲的种族-族裔显著相关,其次是萨摩亚父亲的种族-族裔。
在24 - 42周的孕周范围内,萨摩亚人群体始终呈现出较大的平均出生体重。结果支持了母亲在决定出生体重方面的重要作用。有必要获取更多数据来分析出生大小以及胰岛素生长因子的脐血水平,并开展关于遗传和表观遗传问题的研究。