Crowell David H, Rudoy Raul, Nigg Claudio R, Sharma Santosh, Baruffi Gigliola
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Hawaii Med J. 2010 Sep;69(9):216-20.
Comprehensive birth weight analyses of single primiparous infants of Samoan, Caucasian, Chinese, Filipino, Hawaiian/Part Hawaiian, Japanese racial ethnic groups. Sampling of intrauterine growth designed to reflect antecedent intra- and extra-environmental factors and insure uniform racial-ethnic data for any later genetic and phenotypic birth weight modeling.
Based upon predetermined relevant gestational age criteria, 121, 197 single primiparous infants birth weight records analyzed. The racial-ethnic basic research paradigms also specified parental diallelic crosses representing intra-and inter-ethnic racial ancestry. Hypotheses tested: 1) the mean birth weight of single primiparous infants of Samoan parentage will be significantly larger than the mean birth weight of similar single primiparous infants of Caucasian, Chinese, Filipino, Hawaiian/Part Hawaiian, and Japanese parentage; 2) mean birth weight of single primiparous infants of only Samoan intra-parentage will be significantly larger t han the mean birth weights of single primiparous infants of only Caucasian, Chinese, Filipino, Hawaiian/Part Hawaiian, and Japanese parentage and 3) mean birth weight of single primiparous infants Samoan mothers and non-Samoan fathers will be significantly larger than single primiparous infants of Caucasian, Chinese, Filipino, Hawaiian/Part Hawaiian, and Japanese mothers and non-Caucasian, non-Chinese, non-Filipino, non-Hawaii/Part Hawaiian and non-Japanese father.
Two of three proposed associated hypotheses adopted: namely, that the mean birth weight of single primiparous infants of one, primary Samoan maternal parentage, and two, of only Samoan maternal and paternal parentage, will be significantly larger than their comparative counterparts. Hypotheses 3 based on Samoan mothers and non-Samoan fathers is tenable, but questionable relative to Caucasian parental background. Research highlights importance of control for potentially confounding variables and assets inherent in independent racial-ethnic cohort investigations.
对萨摩亚、高加索、中国、菲律宾、夏威夷/部分夏威夷、日本种族群体的初产单胎婴儿的出生体重进行全面分析。进行宫内生长取样，以反映先前的宫内和宫外环境因素，并确保为任何后续的出生体重遗传和表型建模提供统一的种族数据。
根据预先确定的相关孕周标准，分析了121,197例初产单胎婴儿的出生体重记录。种族基本研究范式还指定了代表种族内和种族间血统的亲本双等位基因杂交。检验的假设：1）萨摩亚血统的初产单胎婴儿的平均出生体重将显著高于高加索、中国、菲律宾、夏威夷/部分夏威夷、日本血统的类似初产单胎婴儿的平均出生体重；2）仅萨摩亚族内亲本的初产单胎婴儿的平均出生体重将显著高于仅高加索、中国、菲律宾、夏威夷/部分夏威夷、日本血统的初产单胎婴儿的平均出生体重；3）萨摩亚母亲和非萨摩亚父亲的初产单胎婴儿的平均出生体重将显著高于高加索、中国、菲律宾、夏威夷/部分夏威夷、日本母亲和非高加索、非中国、非菲律宾、非夏威夷/部分夏威夷、非日本父亲的初产单胎婴儿。
三个提出的相关假设中有两个被采纳：即，一是具有主要萨摩亚母系血统的初产单胎婴儿的平均出生体重，二是仅具有萨摩亚母系和父系血统的初产单胎婴儿的平均出生体重，将显著高于其对照对象。基于萨摩亚母亲和非萨摩亚父亲的假设3是成立的，但相对于高加索亲本背景存在疑问。研究强调了控制潜在混杂变量的重要性以及独立种族队列研究中固有的优势。
