铜催化的高效多组分反应：2-(磺酰亚氨基)-4-(烷基亚氨基)氮杂环丁烷衍生物的合成

Copper-catalyzed highly efficient multicomponent reactions: synthesis of 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives.

作者信息

Xu Xiaoliang, Cheng Dongping, Li Jinghua, Guo Hongyun, Yan Jie

机构信息

College of Chemical Engineering and Materials Science and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.

出版信息

Org Lett. 2007 Apr 12;9(8):1585-7. doi: 10.1021/ol070485x. Epub 2007 Mar 24.

DOI:10.1021/ol070485x

PMID:17381100

Abstract

[reaction: see text] Under very mild conditions, functionalized 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives were prepared in good to excellent yields via a copper-catalyzed multicomponent reaction of readily available terminal alkynes, sulfonyl azides, and carbodiimides without the assistance of a base. The mechanism may be through a [2 + 2] cycloaddition.

摘要

[反应：见正文] 在非常温和的条件下，通过铜催化的易得末端炔烃、磺酰叠氮化物和碳二亚胺的多组分反应，无需碱的辅助，以良好至优异的产率制备了功能化的2-(磺酰基亚氨基)-4-(烷基亚氨基)氮杂环丁烷衍生物。其机理可能是通过[2 + 2]环加成反应。