Egorov V, Tsyuryupa S, Kanilo S, Kogit M, Sarvazyan A
Artann Laboratories, Trenton, NJ, USA.
Med Eng Phys. 2008 Mar;30(2):206-12. doi: 10.1016/j.medengphy.2007.02.007. Epub 2007 Mar 23.
We have developed a device entitled the 'Tissue Elastometer' (TE) for evaluating the Young's modulus of soft tissues. Soft tissue specimens are compressed between the object plate of an electronic balance and a linearly actuated indenter with a small rounded tip. The hardware of the device was designed such that a deformation model for semi-infinite media is applicable for calculating the Young's modulus of test specimens from their collected force-displacement data. Force-elongation measurements were performed on long strips of cured silicone mixtures to produce calibrated, tissue-mimicking test samples for the TE in a Young's modulus range of 10-400 kPa. When tested with the TE, the Young's moduli of the silicone samples demonstrated accuracy to within 1-10% of their calibrated values. Testing on excised tissue samples (fresh store-bought poultry breast; bovine liver, kidneys, hind shanks; porcine) was also performed, and a repeatability of elasticity measurements was demonstrated in the range of 8-14%. Results indicate that the TE can be effectively used in laboratory and clinical environments to evaluate the elasticity modulus of tissues.
我们开发了一种名为“组织弹性仪”(TE)的设备,用于评估软组织的杨氏模量。软组织样本被压缩在电子天平的载物盘和一个带有小圆形尖端的线性驱动压头之间。该设备的硬件设计使得半无限介质的变形模型适用于根据采集到的力-位移数据计算测试样本的杨氏模量。对固化硅酮混合物的长条进行力-伸长测量,以制备校准的、模拟组织的测试样本,用于杨氏模量范围为10-400 kPa的TE。用TE进行测试时,硅酮样本的杨氏模量显示出与校准值的偏差在1-10%以内。还对切除的组织样本(新鲜的市售鸡胸肉;牛肝、肾脏、后小腿;猪)进行了测试,弹性测量的重复性在8-14%范围内得到了证明。结果表明,TE可有效地用于实验室和临床环境中评估组织的弹性模量。