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利用生物组件构建无阀阻抗泵:进展与挑战

Building Valveless Impedance Pumps From Biological Components: Progress and Challenges.

作者信息

Sarvazyan Narine

机构信息

Department of Pharmacology and Physiology, School of Medicine and Health Science, The George Washington University, Washington, DC, United States.

出版信息

Front Physiol. 2022 Jan 31;12:770906. doi: 10.3389/fphys.2021.770906. eCollection 2021.

Abstract

Valveless pumping based on Liebau mechanism entails asymmetrical positioning of the compression site relative to the attachment sites of the pump's elastic segment to the rest of the circuit. Liebau pumping is believed to play a key role during heart development and be involved in several other physiological processes. Until now studies of Liebau pump have been limited to numerical analyses, modeling, experiments using non-biological elements, and a few indirect measurements. This review aims to stimulate experimental efforts to build Liebau pumps using biologically compatible materials in order to encourage further exploration of the fundamental mechanisms behind valveless pumping and its role in organ physiology. The covered topics include the biological occurrence of Liebau pumps, the main differences between them and the peristaltic flow, and the potential uses and body sites that can benefit from implantable valveless pumps based on Liebau principle. We then provide an overview of currently available tools to build such pumps and touch upon limitations imposed by the use of biological components. We also talk about the many variables that can impact Liebau pump performance, including the concept of resonant frequencies, the shape of the flowrate-frequency relationship, the flow velocity profiles, and the Womersley numbers. Lastly, the choices of materials to build valveless impedance pumps and possible modifications to increase their flow output are briefly discussed.

摘要

基于利鲍机制的无阀泵送需要压缩部位相对于泵的弹性段与回路其余部分的连接部位不对称定位。利鲍泵送被认为在心脏发育过程中起关键作用,并参与其他一些生理过程。到目前为止,对利鲍泵的研究仅限于数值分析、建模、使用非生物元件的实验以及一些间接测量。本综述旨在激发使用生物相容性材料构建利鲍泵的实验努力,以鼓励进一步探索无阀泵送背后的基本机制及其在器官生理学中的作用。涵盖的主题包括利鲍泵的生物学存在、它们与蠕动流的主要区别,以及基于利鲍原理的可植入无阀泵的潜在用途和可受益的身体部位。然后,我们概述了目前用于构建此类泵的工具,并提及了使用生物组件所带来的限制。我们还讨论了许多可能影响利鲍泵性能的变量,包括共振频率的概念、流量 - 频率关系的形状、流速分布以及沃默斯利数。最后,简要讨论了构建无阀阻抗泵的材料选择以及可能的改进措施以增加其流量输出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1b/8842681/501260a6c4b2/fphys-12-770906-g001.jpg

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