Kimbrough R D, Squire R A, Linder R E, Strandberg J D, Montalli R J, Burse V W
J Natl Cancer Inst. 1975 Dec;55(6):1453-9. doi: 10.1093/jnci/55.6.1453.
Sherman strain female rats (200) were fed 100 ppm of polychlorinated biphenyl (Aroclor 1260) for apporximately 21 months, and 200 female rats were kept as controls. The rats were killed when 23 months old. Twenty-six of 184 experimental animals and 1 of 173 controls had hepatocellular carcinomas. None of the controls but 146 of 184 experimental rats had neoplastic nodules in their livers, and areas of hepatocellular alteration were noted in 28 of 173 controls and 182 of 184 experimental animals. Thus the polychlorinated biphenyl Aroclor 1260, when fed in the diet, had a hepatocarcinogenic effect in these rats. The incidence of tumors in other organs did not differ appreciably between the experimental and control groups.
给200只雌性谢尔曼品系大鼠喂食浓度为100 ppm的多氯联苯（Aroclor 1260）约21个月，另外200只雌性大鼠作为对照。大鼠在23月龄时处死。184只实验动物中有26只患肝细胞癌，173只对照动物中有1只患肝细胞癌。对照动物中无一患肿瘤，但184只实验大鼠中有146只肝脏出现肿瘤结节，173只对照动物中有28只出现肝细胞改变区域，184只实验动物中有182只出现肝细胞改变区域。因此，通过饮食摄入多氯联苯Aroclor 1260对这些大鼠具有致癌作用。实验组和对照组其他器官肿瘤的发生率没有明显差异。
