聚电解质胶囊的释放机制。
Release mechanisms for polyelectrolyte capsules.
作者信息
De Geest Bruno G, Sanders Niek N, Sukhorukov Gleb B, Demeester Joseph, De Smedt Stefaan C
机构信息
Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
出版信息
Chem Soc Rev. 2007 Apr;36(4):636-49. doi: 10.1039/b600460c. Epub 2006 Oct 13.
Polyelectrolyte capsules have recently been introduced as new microscopic vehicles which could have high potential in the biomedical field. In this critical review we give an introduction to the layer-by-layer (LbL) technique which is used to fabricate these polyelectrolyte capsules as well as to the different triggers that have been exploited to obtain drug release from these capsules. Furthermore, other types of triggered delivery systems are compared and critically discussed with regard to their clinical relevance. (171 references.).
聚电解质胶囊最近作为新型微观载体被引入，在生物医学领域具有巨大潜力。在这篇综述中，我们介绍了用于制备这些聚电解质胶囊的层层（LbL）技术以及用于实现这些胶囊药物释放的不同触发因素。此外，还对其他类型的触发释放系统的临床相关性进行了比较和批判性讨论。（参考文献171篇）
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