Kim Aleksandr L, Dubrovskii Alexey V, Tikhonenko Sergey A
Moscow Polytechnic University (Moscow Polytech), Bolshaya Semyonovskaya Str., 38, 107023 Moscow, Russia.
Institute of Theoretical and Experimental Biophysics Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia.
Polymers (Basel). 2025 Aug 6;17(15):2149. doi: 10.3390/polym17152149.
The development of layer-by-layer polyelectrolyte microcapsules (PMCs) with defined buffer capacity (BC) is a key task for creating stable systems in biomedicine and materials science. Manganese carbonate (MnCO), which shares properties with CaCO and the ability to form hollow structures, represents a promising alternative. However, its interaction with polyelectrolytes and its influence on BC remain insufficiently studied. This research focuses on determining the BC of PMCs templated on MnCO cores under varying ionic strength (0.22-3 M NaCl) and temperature (60-90 °C), as well as comparing the results with PMCs templated on CaCO and PS cores. It was found that MnCO-based PMCs (PMC) exhibit hybrid behavior between CaCO- and PS-based PMCs: the BC dynamics of PMC and CaCO-based PMCs (PMC) in water are identical. At different ionic strength at pH < 5, the BC of PMCMn and PS-based PMCs (PMC) remains unchanged, while at pH > 8.5, the BC of PMC increases only at 3 M NaCl. The BC of PMC remains stable under heating, whereas the BC of PMC and PMC decreases. These results confirm that the choice of core material dictates PMC functionality, paving the way for adaptive systems in biosensing and controlled drug delivery.
开发具有特定缓冲容量（BC）的逐层聚电解质微胶囊（PMC）是生物医学和材料科学中创建稳定系统的关键任务。碳酸锰（MnCO）与碳酸钙（CaCO）具有共同特性且能够形成中空结构，是一种很有前景的替代材料。然而，其与聚电解质的相互作用及其对缓冲容量的影响仍研究不足。本研究重点在于确定以碳酸锰为核的PMC在不同离子强度（0.22 - 3 M氯化钠）和温度（60 - 90°C）下的缓冲容量，并将结果与以碳酸钙和聚苯乙烯为核的PMC进行比较。研究发现，基于碳酸锰的PMC（PMCMn）在基于碳酸钙和聚苯乙烯的PMC之间表现出混合行为：PMCMn和基于碳酸钙的PMC（PMCCa）在水中的缓冲容量动态相同。在pH < 5的不同离子强度下，PMCMn和基于聚苯乙烯的PMC（PMCPs）的缓冲容量保持不变，而在pH > 8.5时，PMCMn的缓冲容量仅在3 M氯化钠时增加。PMCMn的缓冲容量在加热时保持稳定，而PMCCa和PMCPs的缓冲容量则降低。这些结果证实了核材料的选择决定了PMC的功能，为生物传感和可控药物递送中的自适应系统铺平了道路。
