De Geest Bruno G, Jonas Alain M, Demeester Joseph, De Smedt Stefaan C
Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Langmuir. 2006 May 23;22(11):5070-4. doi: 10.1021/la053368o.
Phenylboronic acids are known to form covalent complexes with polyol compounds such as glucose. A novel polyelectrolyte, containing phenylboronic acid as a glucose-sensitive moiety, has been synthesized and used for the fabrication of glucose-sensitive hollow polyelectrolyte capsules using the layer-by-layer technique. The response to glucose was observed as a rather fast dissolution of the capsules when brought into contact with a glucose-containing medium. These polyelectrolyte capsules are the first polyelectrolyte capsules able to respond to a stimulus that can be provided by the human body (i.e., an increase in glucose concentration). Therefore, the concept we present has promising applications in the biomedical field for the controlled delivery of insulin.
已知苯基硼酸可与多元醇化合物（如葡萄糖）形成共价复合物。一种含有苯基硼酸作为葡萄糖敏感部分的新型聚电解质已被合成，并用于通过层层技术制备葡萄糖敏感的中空聚电解质胶囊。当与含葡萄糖的介质接触时，观察到胶囊对葡萄糖的响应是相当快速的溶解。这些聚电解质胶囊是首批能够对人体提供的刺激（即葡萄糖浓度增加）作出响应的聚电解质胶囊。因此，我们提出的概念在生物医学领域用于胰岛素的控释方面具有广阔的应用前景。
