Vázquez-Tsuji Oscar, Campos Rivera Teresita, Rondán Zárate Adrián, Mirabal García Mónica
Laboratorio de Biología Molecular y Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle, Mexico.
Rev Iberoam Micol. 2006 Dec;23(4):245-8. doi: 10.1016/s1130-1406(06)70054-7.
A case of endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis is presented. The bronchial aspirate's cytology showed the presence of a large amount of septated-dichotomized hyphae. The bronchial aspirate's culture showed the presence of Scedosporium apiospermum in a pure culture of three consecutive samples. The scanning electron microscopy study of the mucosal surface revealed scarce mycelia with the presence of abundant conidiae. The transmission electron microscopy of the mucosa revealed inflammatory infiltrates constituted by macrophages, polymorphonuclear leukocytes, a lot of dichotomized mycelia and macrophages with hyphae and conidiae within the phagosomes. The patient was treated with amphotericin B and itraconazole.
本文报告了1例患有囊性纤维化的儿童发生由尖端赛多孢菌引起的支气管内膜炎的病例。支气管吸出物的细胞学检查显示存在大量有隔膜的二叉分枝菌丝。支气管吸出物的培养显示在连续3个样本的纯培养物中均存在尖端赛多孢菌。对黏膜表面的扫描电子显微镜研究显示菌丝稀少，但有大量分生孢子。黏膜的透射电子显微镜检查显示炎症浸润由巨噬细胞、多形核白细胞、许多二叉分枝菌丝以及吞噬体内含有菌丝和分生孢子的巨噬细胞组成。该患者接受了两性霉素B和伊曲康唑治疗。
