通过对韩国婴儿脐带血DNA进行序列分型鉴定出一种新的HLA - B58等位基因，即B5813。

Identification of a novel HLA-B58 allele, B5813, by sequence-based typing of DNA from Korean baby cord blood.

作者信息

Yoon S, Baek J-Y, Hur S-S, Kwon O-J, Kwack K

机构信息

School of Life Science and Biotechnology, Pochon CHA University, Kyunggi-do 463-836, Korea.

出版信息

Tissue Antigens. 2007 Apr;69(4):366-7. doi: 10.1111/j.1399-0039.2007.00810.x.

DOI:10.1111/j.1399-0039.2007.00810.x

PMID:17389028

Abstract

The novel HLA-B5813 allele was identified in the cord blood of a Korean baby by sequence-based typing. This allele shows a sequence identical to that of HLA-B5801, except for a nucleotide substitution that changes GAG to AAG at codon 128, resulting in an amino acid change from glutamic acid to lysine in the protein.

摘要

通过基于序列的分型方法，在一名韩国婴儿的脐带血中鉴定出了新型HLA - B5813等位基因。该等位基因与HLA - B5801的序列相同，只是在第128密码子处有一个核苷酸替换，将GAG变为AAG，导致蛋白质中的氨基酸从谷氨酸变为赖氨酸。