高同型半胱氨酸血症和低蛋氨酸应激是印度人群中心视网膜静脉阻塞的危险因素。

Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population.

作者信息

Narayanasamy Angayarkanni, Subramaniam Barathi, Karunakaran Coral, Ranganathan Punitham, Sivaramakrishnan Ramakrishnan, Sharma Tarun, Badrinath Vasanthi Sengamedu, Roy Joseph

机构信息

Biochemistry Research Department, Sankara Nethralaya Vision and Medical Research Foundation, 18 College Road, Chennai 600 006, India.

出版信息

Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1441-6. doi: 10.1167/iovs.06-0905.

DOI:10.1167/iovs.06-0905

PMID:17389469

Abstract

PURPOSE

The underlying cause of disturbed homocysteine metabolism is incompletely understood in young persons with central retinal vein occlusion (CRVO) with mild hyperhomocysteinemia (HHcys) and no other systemic disease in India. A 2-year prospective study was undertaken to determine whether HHcys is a risk factor for CRVO in an Indian population.

METHOD

The prevalence of fasting HHcys was evaluated in a consecutive series of 29 patients with CRVO (mean age, 30 +/- 6 years) along with 57 age- and sex-matched control subjects (healthy subjects, mean age 27 +/- 5 years). Strict inclusion and exclusion criteria were used. Plasma levels of homocysteine (Hcys), methionine, cysteine, glutathione, B(12), and folate were measured. Multivariate logistic regression analysis was performed to determine the risk factors for CRVO.

RESULT

Fifteen of 29 patients with CRVO (51.72%) exhibited HHcys (>15 muM). The mean Hcys level was significantly elevated in the patients with CRVO (19.1 +/- 13.1 muM) compared with that in the healthy control subjects (14.7 +/- 6.2 muM) with P = 0.04. The increased Hcys levels in CRVO cases was associated with decreased methionine (P = 0.052) and decreased B(12) (P = 0.001). A multivariate logistic regression analysis revealed an odds ratio of 1.9 (95% CI = 0.50-7.16) for Hcys and 15.9 for methionine (95%CI = 1.50-169.62; P = 0.022).

CONCLUSION

Elevated Hcys and low methionine were risk factors for CRVO in an Indian population.

摘要

目的

在印度，对于患有视网膜中央静脉阻塞（CRVO）且伴有轻度高同型半胱氨酸血症（HHcys）且无其他全身性疾病的年轻人，其同型半胱氨酸代谢紊乱的潜在原因尚未完全明确。开展了一项为期2年的前瞻性研究，以确定HHcys是否为印度人群中CRVO的危险因素。

方法

对连续纳入的29例CRVO患者（平均年龄30±6岁）以及57例年龄和性别匹配的对照受试者（健康受试者，平均年龄27±5岁）进行空腹HHcys患病率评估。采用了严格的纳入和排除标准。检测血浆中同型半胱氨酸（Hcys）、蛋氨酸、半胱氨酸、谷胱甘肽、维生素B12和叶酸的水平。进行多因素逻辑回归分析以确定CRVO的危险因素。

结果

29例CRVO患者中有15例（51.72%）表现出HHcys（>15μM）。与健康对照受试者（14.7±6.2μM）相比，CRVO患者的平均Hcys水平显著升高（19.1±13.1μM），P = 0.04。CRVO病例中Hcys水平升高与蛋氨酸降低（P = 0.052）和维生素B12降低（P = 0.001）相关。多因素逻辑回归分析显示，Hcys的比值比为1.9（95%CI = 0.50 - 7.16），蛋氨酸的比值比为15.9（95%CI = 1.50 - 169.62；P = 0.022）。