Angayarkanni N, Barathi S, Seethalakshmi T, Punitham R, Sivaramakrishna R, Suganeswari G, Tarun S
Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India.
Eye (Lond). 2008 Jul;22(7):969-74. doi: 10.1038/sj.eye.6703062. Epub 2007 Dec 14.
To estimate the arylesterase activity of serum paraoxonase-1 (PON1-ARE), which is reported to have an antioxidant and antiatherogenic potential and to correlate with plasma homocysteine (Hcys) and plasma TBARS in young adult central retinal venous occlusion (CRVO) patients.
A case-control prospective study carried out in 10 CRVO patients (mean age 27+/-5 years; 7 males, 3 females) and 20 healthy controls (mean age 29+/-5 years; 15 males, 5 females).
The CRVO patients showed a significantly lowered serum PON1-ARE activity (P=0.009) along with a significant increase in the levels of plasma Hcys (P=0.018) when compared to the control subjects. There was a negative correlation between serum PON1-ARE and plasma Hcys levels (P=0.058) as well as between PON1-ARE and plasma TBARS levels (P=0.001) in the CRVO patients.
This is the first report of lowered serum PON1-ARE level as a risk factor for CRVO (OR= 1.108, CI=0.914, 1.314; P=0.296), which is found to correlate with oxidative stress.
评估血清对氧磷酶-1的芳基酯酶活性（PON1-ARE），据报道该酶具有抗氧化和抗动脉粥样硬化潜力，并与年轻成年中心性视网膜静脉阻塞（CRVO）患者的血浆同型半胱氨酸（Hcys）及血浆硫代巴比妥酸反应物（TBARS）相关。
对10例CRVO患者（平均年龄27±5岁；男性7例，女性3例）和20例健康对照者（平均年龄29±5岁；男性15例，女性5例）进行病例对照前瞻性研究。
与对照者相比，CRVO患者血清PON1-ARE活性显著降低（P=0.009），同时血浆Hcys水平显著升高（P=0.018）。CRVO患者血清PON1-ARE与血浆Hcys水平之间呈负相关（P=0.058），且PON1-ARE与血浆TBARS水平之间也呈负相关（P=0.001）。
这是首次报道血清PON1-ARE水平降低是CRVO的危险因素（OR=1.108，CI=0.914，1.314；P=0.296），且发现其与氧化应激相关。
