Akbaraly N Tasnime, Faure Henri, Gourlet Veronique, Favier Alain, Berr Claudine
INSERM U888, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier, Cedex 5, France.
J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):308-16. doi: 10.1093/gerona/62.3.308.
The hypothesis of carotenoids having a preventive role in cognitive impairment is suggested by their antioxidant properties.
We examined, in a cross-sectional analysis, the relationship between cognitive performance (assessed by the Mini-Mental State Examination, Trail Making Test Part B, Digit Symbol Substitution, Finger Tapping Test, and Word Fluency Test) and different plasma carotenoids (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and trans-beta-carotene and cis-beta-carotene) in a healthy elderly population (the EVA,"Etude du Vieillissement Artériel," study; n = 589, age = 73.5 +/- 3 years).
Logistic regression showed that participants with the lowest cognitive functioning (<25th percentile) had a higher probability of having low levels of specific plasma carotenoids (<1st quartile): lycopene and zeaxanthin. For zeaxanthin, odds ratios (ORs) were as follows: OR(DSS) = 1.97 (95% confidence interval [CI] = 1.21-3.20), OR(FTT) = 1.70 (CI = 1.05-2.74), and OR(WFT) = 1.82 (CI = 1.08-3.07); for lycopene, OR(DSS) = 1.93 (CI = 1.20-3.12) and OR(TMTB) = 1.64 (CI = 1.04-2.59).
Even if it is not possible to affirm if these low levels of carotenoids precede or are the consequence of cognitive impairment, our results suggest that low carotenoid levels could play a role in cognitive impairment. The biological significance of our findings needs further research.
类胡萝卜素因其抗氧化特性而被认为对认知障碍具有预防作用。
在一项横断面分析中，我们研究了健康老年人群（“动脉老化研究”，即EVA研究；n = 589，年龄 = 73.5 ± 3岁）的认知表现（通过简易精神状态检查表、连线测验B部分、数字符号替换、手指敲击测验和词语流畅性测验进行评估）与不同血浆类胡萝卜素（叶黄素、玉米黄质、β - 隐黄质、番茄红素、α - 胡萝卜素、反式β - 胡萝卜素和顺式β - 胡萝卜素）之间的关系。
逻辑回归显示，认知功能最低（<第25百分位数）的参与者血浆中特定类胡萝卜素水平低（<第一四分位数）的可能性更高，这些类胡萝卜素为番茄红素和玉米黄质。对于玉米黄质，优势比（OR）如下：OR（数字符号替换）= 1.97（95%置信区间[CI] = 1.21 - 3.20），OR（手指敲击测验）= 1.70（CI = 1.05 - 2.74），OR（词语流畅性测验）= 1.82（CI = 1.08 - 3.07）；对于番茄红素，OR（数字符号替换）= 1.93（CI = 1.20 - 3.12），OR（连线测验B部分）= 1.64（CI = 1.04 - 2.59）。
即使无法确定这些低水平类胡萝卜素是先于认知障碍出现还是认知障碍的结果，但我们的结果表明低类胡萝卜素水平可能在认知障碍中起作用。我们研究结果的生物学意义需要进一步研究。
