老年人群血浆类胡萝卜素水平与认知能力：EVA研究结果

Plasma carotenoid levels and cognitive performance in an elderly population: results of the EVA Study.

作者信息

Akbaraly N Tasnime, Faure Henri, Gourlet Veronique, Favier Alain, Berr Claudine

机构信息

INSERM U888, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier, Cedex 5, France.

出版信息

J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):308-16. doi: 10.1093/gerona/62.3.308.

DOI:10.1093/gerona/62.3.308

PMID:17389729

Abstract

BACKGROUND

The hypothesis of carotenoids having a preventive role in cognitive impairment is suggested by their antioxidant properties.

METHODS

We examined, in a cross-sectional analysis, the relationship between cognitive performance (assessed by the Mini-Mental State Examination, Trail Making Test Part B, Digit Symbol Substitution, Finger Tapping Test, and Word Fluency Test) and different plasma carotenoids (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and trans-beta-carotene and cis-beta-carotene) in a healthy elderly population (the EVA,"Etude du Vieillissement Artériel," study; n = 589, age = 73.5 +/- 3 years).

RESULTS

Logistic regression showed that participants with the lowest cognitive functioning (<25th percentile) had a higher probability of having low levels of specific plasma carotenoids (<1st quartile): lycopene and zeaxanthin. For zeaxanthin, odds ratios (ORs) were as follows: OR(DSS) = 1.97 (95% confidence interval [CI] = 1.21-3.20), OR(FTT) = 1.70 (CI = 1.05-2.74), and OR(WFT) = 1.82 (CI = 1.08-3.07); for lycopene, OR(DSS) = 1.93 (CI = 1.20-3.12) and OR(TMTB) = 1.64 (CI = 1.04-2.59).

CONCLUSION

Even if it is not possible to affirm if these low levels of carotenoids precede or are the consequence of cognitive impairment, our results suggest that low carotenoid levels could play a role in cognitive impairment. The biological significance of our findings needs further research.

摘要

背景

类胡萝卜素因其抗氧化特性而被认为对认知障碍具有预防作用。

方法

在一项横断面分析中，我们研究了健康老年人群（“动脉老化研究”，即EVA研究；n = 589，年龄 = 73.5 ± 3岁）的认知表现（通过简易精神状态检查表、连线测验B部分、数字符号替换、手指敲击测验和词语流畅性测验进行评估）与不同血浆类胡萝卜素（叶黄素、玉米黄质、β - 隐黄质、番茄红素、α - 胡萝卜素、反式β - 胡萝卜素和顺式β - 胡萝卜素）之间的关系。

结果

逻辑回归显示，认知功能最低（<第25百分位数）的参与者血浆中特定类胡萝卜素水平低（<第一四分位数）的可能性更高，这些类胡萝卜素为番茄红素和玉米黄质。对于玉米黄质，优势比（OR）如下：OR（数字符号替换）= 1.97（95%置信区间[CI] = 1.21 - 3.20），OR（手指敲击测验）= 1.70（CI = 1.05 - 2.74），OR（词语流畅性测验）= 1.82（CI = 1.08 - 3.07）；对于番茄红素，OR（数字符号替换）= 1.93（CI = 1.20 - 3.12），OR（连线测验B部分）= 1.64（CI = 1.04 - 2.59）。