Acharya G, Sitras V, Erkinaro T, Mäkikallio K, Kavasmaa T, Päkkilä M, Huhta J C, Räsänen J
Department of Obstetrics and Gynecology, Faculty of Medicine University of Tromsø and University Hospital of Northern Norway, Tromsø, Norway.
Ultrasound Obstet Gynecol. 2007 Apr;29(4):401-6. doi: 10.1002/uog.3977.
To test the hypothesis that Doppler-derived (calculated) uterine artery volume blood flow (cQ(UtA)) reflects accurately volume blood flow measured directly (mQ(UtA)) in an experimental setting.
Five pregnant sheep were instrumented at 122-130 days of gestation under general anesthesia. After a 4-day recovery period, maternal hemodynamics were varied by administering to the sheep under general anesthesia noradrenaline, beta-blocker, low oxygen gas mixture, epidural bupivacaine and ephedrine, consecutively. The central venous pressure was obtained with the help of a thermodilution catheter. The mean arterial pressure and acid-base status were monitored using a 16-gauge polyurethane catheter inserted into the descending aorta via a femoral artery. A 6-mm transit-time ultrasonic perivascular flow probe was used to measure the mQ(UtA). Doppler ultrasonography of the uterine artery was performed and volume blood flow was obtained simultaneously by the transit-time ultrasonic perivascular flow probe during each phase of the experiment.
A total of 31 observations were made. The mQ(UtA) varied between 90 and 800 (mean +/- SD, 419 +/- 206) mL/min during the experiments. The corresponding values for the cQ(UtA) were 110 and 900 (mean +/- SD, 459 +/- 211) mL/min. There was a significant correlation (R = 0.76; P < 0.0001) between mQ(UtA) and cQ(UtA). The mQ(UtA) correlated positively with Doppler-derived uterine artery absolute velocities, i.e. peak systolic (R = 0.50; P = 0.004), end-diastolic (R = 0.53; P = 0.002) and time-averaged maximum (R = 0.69; P < 0.0001) and time-averaged intensity weighted mean (R = 0.75; P < 0.0001) velocities.
cQ(UtA) correlates well with volume blood flow measured directly. Doppler-derived uterine artery absolute blood flow velocities reflect uteroplacental volume blood flow in pregnant sheep. Published by John Wiley & Sons, Ltd.
验证在实验环境中，经多普勒推导（计算）得出的子宫动脉容积血流量（cQ(UtA)）能够准确反映直接测量的容积血流量（mQ(UtA)）这一假设。
对5只妊娠母羊在妊娠122 - 130天时进行全身麻醉并植入监测仪器。经过4天的恢复期后，在全身麻醉状态下依次给母羊注射去甲肾上腺素、β受体阻滞剂、低氧混合气体、硬膜外布比卡因和麻黄碱，以改变母体血流动力学。借助热稀释导管获取中心静脉压。使用一根16号聚氨酯导管经股动脉插入降主动脉，监测平均动脉压和酸碱状态。使用一个6毫米的渡越时间超声血管外血流探头测量mQ(UtA)。在实验的每个阶段，对子宫动脉进行多普勒超声检查，并通过渡越时间超声血管外血流探头同时获取容积血流量。
共进行了31次观察。实验期间，mQ(UtA)在90至800（均值±标准差，419±206）毫升/分钟之间变化。cQ(UtA)的相应值为110至900（均值±标准差，459±211）毫升/分钟。mQ(UtA)与cQ(UtA)之间存在显著相关性（R = 0.76；P < 0.0001）。mQ(UtA)与经多普勒推导得出的子宫动脉绝对速度呈正相关，即收缩期峰值（R = 0.50；P = 0.004）、舒张末期（R = 0.53；P = 0.002）、时间平均最大（R = 0.69；P < 0.0001）以及时间平均强度加权平均（R = 0.75；P < 0.0001）速度。
cQ(UtA)与直接测量的容积血流量具有良好的相关性。经多普勒推导得出的子宫动脉绝对血流速度反映了妊娠母羊子宫胎盘的容积血流量。由约翰·威利父子有限公司出版。
