Costandi Peter N, McCulloch Andrew D, Omens Jeffrey H, Frank Lawrence R
Department of Bioengineering, University of California-San Diego, La Jolla, California 92093-0613, USA.
Magn Reson Med. 2007 Apr;57(4):714-20. doi: 10.1002/mrm.21182.
The development of heart failure (HF) is an evolving process that entails both structural and functional changes through time. While the physiological state of cardiac pathologies has been well characterized, less is known about the transition from a normal to a maladaptive state. Magnetic resonance imaging (MRI) is a noninvasive technique that facilitates longitudinal experiments to follow the progression of cardiac structural and physiological disorders over time. Transgenic murine models of cardiac disease, such as the muscle LIM protein-deficient strain used in this study, offer populations of a reproducible phenotype that readily lend themselves to serial studies. In this longitudinal study, high spatial and temporal resolution time-course MR images revealed an abrupt and brief phase of major anatomical restructuring during which the ventricular chamber dilated and the wall thinned. The ability of MRI to acquire spatially and temporally resolved images enabled the 3D estimation of cavity volume and wall mass changes with time. It was concluded that, using an imaging protocol of high temporal resolution, MRI has the adequate spatial and temporal imaging resolution to allow for the detection and quantification of rapidly occurring transitional phases in a single mouse heart as it progresses toward failure.
心力衰竭（HF）的发展是一个不断演变的过程，随着时间的推移会出现结构和功能的变化。虽然心脏病理的生理状态已得到充分表征，但对于从正常状态到适应不良状态的转变了解较少。磁共振成像（MRI）是一种非侵入性技术，有助于进行纵向实验，以跟踪心脏结构和生理紊乱随时间的进展。心脏病的转基因小鼠模型，如本研究中使用的肌肉LIM蛋白缺陷菌株，提供了具有可重复表型的群体，易于进行系列研究。在这项纵向研究中，高空间和时间分辨率的时程MR图像显示了一个主要解剖结构重组的突然且短暂的阶段，在此期间心室腔扩张且壁变薄。MRI获取空间和时间分辨图像的能力使得能够对腔体积和壁质量随时间的变化进行三维估计。得出的结论是，使用高时间分辨率的成像方案，MRI具有足够的空间和时间成像分辨率，能够在单个小鼠心脏向衰竭发展的过程中检测和量化快速发生的过渡阶段。
