Short-Term Efficacy of Pudilan Keyanning Toothpaste in Treatment of Minor Recurrent Aphthous Ulcers.

. To examine the potential of Pudilan Keyanning toothpaste (PKT) to treat minor aphthous ulcers (MiAU). . A double-blind clinical trial was conducted in which 80 volunteers were randomly assigned to the PKT group ( = 40) or the control group ( = 40). The control group used a placebo toothpaste containing no Pudilan extract. At baseline, after 3 days, and after 6 days the following parameters were recorded for the target ulcers: healing rate, healing period, pain (visual analogue scale, VAS), areas of the target ulcerated lesions, degree of exudation, and hyperemia. . At the end of the study, the healing rate in the PKT group was 80%, compared to 50% in the control group ( < 0.05). At day 6, the VAS scores, ulcer area, degree of exudation, and hyperemia were significantly different between the two groups, with better performance observed in the PKT group ( < 0.05). . PKT toothpaste appears to promote effective healing of MiAU.