Myhra W, Davis M, Mueller B A, Hickok D
Department of Epidemiology, University of Washington, Seattle.
Am J Public Health. 1992 Feb;82(2):176-9. doi: 10.2105/ajph.82.2.176.
Washington State birth certificates were used to conduct a population-based case-control study to assess the possible association of maternal smoking with polyhydramnios.
All singleton births complicated by polyhydramnios (n = 557) were identified from the vital records for the years 1984 to 1987. For comparison, 1671 records were randomly selected for the same years from singleton births uncomplicated by polyhydramnios.
Women who reportedly smoked prenatally were found to be at increased risk for polyhydramnios (relative risk [RR] = 1.7, 95% confidence interval [CI] = 1.5-2.1, adjusted for marital status, maternal age, and parity). When women with conditions known to be associated with polyhydramnios were excluded, the risk for those who smoked prenatally remained elevated (RR = 1.8, 95% CI = 1.1-2.3).
Overdistention of the uterus from polyhydramnios may cause a variety of pregnancy complications. The observed association of smoking with polyhydramnios may be a further indication for public health interventions aimed at preventing smoking during pregnancy.
利用华盛顿州出生证明开展一项基于人群的病例对照研究，以评估孕妇吸烟与羊水过多之间的可能关联。
从1984年至1987年的生命记录中识别出所有并发羊水过多的单胎分娩（n = 557）。作为对照，从同一时期未并发羊水过多的单胎分娩记录中随机选取1671份。
据报告产前吸烟的女性被发现羊水过多风险增加（相对风险[RR]=1.7，95%置信区间[CI]=1.5 - 2.1，经婚姻状况、产妇年龄和产次调整）。排除已知与羊水过多相关疾病的女性后，产前吸烟女性的风险仍然升高（RR = 1.8，95% CI = 1.1 - 2.3）。
羊水过多导致的子宫过度扩张可能会引起多种妊娠并发症。观察到的吸烟与羊水过多之间的关联可能是针对孕期预防吸烟的公共卫生干预的进一步指征。
