细胞增殖、细胞死亡及肿瘤发生过程中的微小RNA

MicroRNAs in cell proliferation, cell death, and tumorigenesis.

作者信息

Hwang H-W, Mendell J T

机构信息

Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Br J Cancer. 2007;96 Suppl:R40-4.

PMID:17393584

Abstract

MicroRNAs (miRNAs) are a recently discovered class of approximately 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

摘要

微小RNA（miRNA）是最近发现的一类由大约18 - 24个核苷酸组成的RNA分子，它们对靶mRNA具有负调控作用。所有已研究的多细胞真核生物都利用miRNA来调节包括增殖、分化和死亡在内的基本细胞功能。现在很明显，miRNA表达异常是人类恶性肿瘤的一个共同特征。在这篇综述中，我们将讨论miRNA如何作为癌基因和肿瘤抑制因子影响肿瘤发生。