超越人乳头瘤病毒：致癌miRNA成为宫颈癌的新角色

Beyond HPV: oncomirs as new players in cervical cancer.

作者信息

Reshmi G, Pillai M Radhakrishna

机构信息

Translational Cancer Research Laboratory, Rajiv Gandhi Center for Biotechnology, Thycaud P.O., Thiruvananthapuram 695 014, Kerala, India.

出版信息

FEBS Lett. 2008 Dec 24;582(30):4113-6. doi: 10.1016/j.febslet.2008.11.011. Epub 2008 Nov 24.

DOI:10.1016/j.febslet.2008.11.011

PMID:19032954

Abstract

MicroRNAs (miRNAs) are a recently discovered family of 18-24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.

摘要

微小RNA（miRNA）是最近发现的一类由18 - 24个核苷酸组成的非编码RNA，可对靶mRNA进行负调控。所有已研究的多细胞真核生物都利用miRNA来调节包括增殖、分化和死亡在内的基本细胞功能。现在很明显，miRNA表达异常是人类恶性肿瘤的一个共同特征。本综述讨论了各种与癌症相关的miRNA（致癌miRNA），特别是在宫颈癌发生过程中的作用，以及致癌miRNA作为治疗宫颈癌的治疗药物和靶点的潜在作用。