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How reliable are current docking approaches for structure-based drug design? Lessons from aldose reductase.

作者信息

Zentgraf Matthias, Steuber Holger, Koch Cornelia, La Motta Concettina, Sartini Stefania, Sotriffer Christoph A, Klebe Gerhard

机构信息

Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.

出版信息

Angew Chem Int Ed Engl. 2007;46(19):3575-8. doi: 10.1002/anie.200603625.

DOI:10.1002/anie.200603625

PMID:17394265

Abstract

摘要

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How reliable are current docking approaches for structure-based drug design? Lessons from aldose reductase.

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How reliable are current docking approaches for structure-based drug design? Lessons from aldose reductase.

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