Piscopo Tonio V, Mallia Azzopardi Charles
St Luke's Hospital, Guardamangia Hill, Guardamangia, MSD 09, Malta.
Postgrad Med J. 2007 Feb;83(976):649-57. doi: 10.1136/pgmj.2006.047340corr1.
Epidemiology, disease patterns, immunology, diagnosis, treatment and control measures of leishmaniasis are described. Various issues relating to leishmaniasis are highlighted: the relative lack of importance given to this disease compared with other infections, climate change and its possible impact on extension of endemicity of this infection, and new diagnostic tests which are improving diagnosis, especially in resource poor areas. Other important aspects discussed include the potential for newer oral therapy to change the way this disease is managed; Leishmania-HIV coinfection and groups at risk; and development of an effective vaccine.
本文描述了利什曼病的流行病学、疾病模式、免疫学、诊断、治疗及控制措施。文中强调了与利什曼病相关的各种问题:与其他感染相比,该疾病相对缺乏重视;气候变化及其对这种感染流行范围扩大的可能影响;以及正在改善诊断的新诊断测试,尤其是在资源匮乏地区。讨论的其他重要方面包括新型口服疗法改变该疾病管理方式的潜力;利什曼病与艾滋病毒合并感染及高危人群;以及有效疫苗的研发。