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一种在荟萃分析中推断总体效应的简单方法。

A simple method for inference on an overall effect in meta-analysis.

作者信息

Brockwell Sarah E, Gordon Ian R

机构信息

Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA15261, U.S.A.

出版信息

Stat Med. 2007 Nov 10;26(25):4531-43. doi: 10.1002/sim.2883.

Abstract

The random effects approach in meta-analysis due to DerSimonian and Laird is well established and used pervasively. It has been established by Brockwell and Gordon that this method, when used for confidence intervals, leads to coverage probabilities lower than the nominal value. A number of alternatives have been proposed, but these either have the defect of iterative and complicated calculation, or deficient coverage. In this paper we propose a new approach, which is simple to use, and has coverage probabilities better than the alternatives, based on extensive simulation. We call this approach the 'quantile approximation' method.

摘要

由DerSimonian和Laird提出的荟萃分析中的随机效应方法已得到广泛认可和普遍应用。Brockwell和Gordon已经证实,当该方法用于置信区间时,其覆盖概率低于名义值。人们已经提出了许多替代方法,但这些方法要么存在迭代计算复杂的缺陷,要么覆盖不足。在本文中,我们基于广泛的模拟提出了一种新方法,该方法使用简单,且覆盖概率优于其他替代方法。我们将这种方法称为“分位数近似”法。

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