Nisar M, Adzu B, Inamullah K, Bashir A, Ihsan A, Gilani A H
Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Phytother Res. 2007 Jul;21(7):693-5. doi: 10.1002/ptr.2139.
A methanol extract of Zizyphus oxyphylla Edgew leaves has been investigated for its analgesic and antipyretic activities in Adult Wistar and Swiss albino mice of either sex at 50, 100 and 200 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast-induced pyrexia in rats. The extract demonstrated significant peripheral analgesic effect in the acetic acid-induced writhing test in mice. The phytochemical tests revealed that the extract contained alkaloids, anthraquinones, flavonoids, glycosides, phenols, resins, saponins and tannins using standard procedures. In conclusion, the present study suggests that the methanol extract of Zizyphus oxyphylla Edgew leaves possesses potent antipyretic and antinociceptive activities and thus validates its use in the treatment of pain and fever.
对酸叶枣（Zizyphus oxyphylla Edgew）叶的甲醇提取物进行了研究，以考察其对成年Wistar和瑞士白化病小鼠（雌雄不限）口服50、100和200mg/kg时的镇痛和解热活性。该提取物对啤酒酵母诱导的大鼠发热表现出显著的解热活性。在小鼠醋酸诱导扭体试验中，该提取物表现出显著的外周镇痛作用。采用标准方法进行的植物化学试验表明，该提取物含有生物碱、蒽醌、黄酮类、糖苷、酚类、树脂、皂苷和单宁。总之，本研究表明酸叶枣叶的甲醇提取物具有强大的解热和抗伤害感受活性，从而验证了其在治疗疼痛和发热方面的用途。
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